Decoding cis-regulatory DNAs in the Drosophila genome

Cis-regulatory DNAs control the timing and sites of gene expression during metazoan development. Changes in gene expression are responsible for the morphological diversification of metazoan body plans. However, traditional methods for the identification and characterization of cis-regulatory DNAs ar...

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Bibliographic Details
Published inCurrent Opinion in Genetics & Development Vol. 12; no. 5; pp. 601 - 606
Main Authors Markstein, Michele, Levine, Michael
Format Book Review Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2002
Subjects
Animals
Binding Sites - genetics
Body Patterning - genetics
cis-regulatory
computational analysis
Computational Biology
DNA
Drosophila melanogaster - embryology
Drosophila melanogaster - genetics
Drosophila melanogaster - metabolism
enhancer
Genes, Insect
Genes, Regulator
Genome
metazoa
Multigene Family
Promoter Regions, Genetic
Regulatory Sequences, Nucleic Acid
Transcription Factors - metabolism
Transcription, Genetic
enhancer
DNA
metazoa
Development
Evolution
Genetics
cis-regulatory
computational analysis
Bioinformatics
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Summary:Cis-regulatory DNAs control the timing and sites of gene expression during metazoan development. Changes in gene expression are responsible for the morphological diversification of metazoan body plans. However, traditional methods for the identification and characterization of cis-regulatory DNAs are tedious. During the past year, computational methods have been used to identify novel cis-DNAs within the entire Drosophila genome. These methods change the way that cis-DNAs will be analyzed in future studies and offer the promise of unraveling complex gene networks.
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ISSN:0959-437X
1879-0380
DOI:10.1016/S0959-437X(02)00345-3