Behavioral Deficits in Animal Models of Blast Traumatic Brain Injury
Blast exposure has been identified to be the most common cause for traumatic brain injury (TBI) in soldiers. Over the years, rodent models to mimic blast exposures and the behavioral outcomes observed in veterans have been developed extensively. However, blast tube design and varying experimental pa...
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Published in | Frontiers in neurology Vol. 11; p. 990 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
04.09.2020
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Abstract | Blast exposure has been identified to be the most common cause for traumatic brain injury (TBI) in soldiers. Over the years, rodent models to mimic blast exposures and the behavioral outcomes observed in veterans have been developed extensively. However, blast tube design and varying experimental parameters lead to inconsistencies in the behavioral outcomes reported across research laboratories. This review aims to curate the behavioral outcomes reported in rodent models of blast TBI using shockwave tubes or open field detonations between the years 2008–2019 and highlight the important experimental parameters that affect behavioral outcome. Further, we discuss the role of various design parameters of the blast tube that can affect the nature of blast exposure experienced by the rodents. Finally, we assess the most common behavioral tests done to measure cognitive, motor, anxiety, auditory, and fear conditioning deficits in blast TBI (bTBI) and discuss the advantages and disadvantages of these tests. |
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AbstractList | Blast exposure has been identified to be the most common cause for traumatic brain injury (TBI) in soldiers. Over the years, rodent models to mimic blast exposures and the behavioral outcomes observed in veterans have been developed extensively. However, blast tube design and varying experimental parameters lead to inconsistencies in the behavioral outcomes reported across research laboratories. This review aims to curate the behavioral outcomes reported in rodent models of blast TBI using shockwave tubes or open field detonations between the years 2008–2019 and highlight the important experimental parameters that affect behavioral outcome. Further, we discuss the role of various design parameters of the blast tube that can affect the nature of blast exposure experienced by the rodents. Finally, we assess the most common behavioral tests done to measure cognitive, motor, anxiety, auditory, and fear conditioning deficits in blast TBI (bTBI) and discuss the advantages and disadvantages of these tests. |
Author | Ravula, Arun Reddy Chandra, Namas Aravind, Aswati Pfister, Bryan J. |
AuthorAffiliation | Department of Biomedical Engineering, Center for Injury Biomechanics, Materials and Medicine, New Jersey Institute of Technology , Newark, NJ , United States |
AuthorAffiliation_xml | – name: Department of Biomedical Engineering, Center for Injury Biomechanics, Materials and Medicine, New Jersey Institute of Technology , Newark, NJ , United States |
Author_xml | – sequence: 1 givenname: Aswati surname: Aravind fullname: Aravind, Aswati – sequence: 2 givenname: Arun Reddy surname: Ravula fullname: Ravula, Arun Reddy – sequence: 3 givenname: Namas surname: Chandra fullname: Chandra, Namas – sequence: 4 givenname: Bryan J. surname: Pfister fullname: Pfister, Bryan J. |
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Copyright | Copyright © 2020 Aravind, Ravula, Chandra and Pfister. 2020 Aravind, Ravula, Chandra and Pfister |
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Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 Edited by: Denes V. Agoston, Karolinska Institutet (KI), Sweden This article was submitted to Neurotrauma, a section of the journal Frontiers in Neurology Reviewed by: Samar Abdelhady, Faculty of Medicine, Alexandria University, Egypt; Alana Conti, Wayne State University, United States |
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Snippet | Blast exposure has been identified to be the most common cause for traumatic brain injury (TBI) in soldiers. Over the years, rodent models to mimic blast... |
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StartPage | 990 |
SubjectTerms | anxiety and depression auditory deficits behavior deficits blast TBI cognitive deficits motor deficits Neurology |
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Title | Behavioral Deficits in Animal Models of Blast Traumatic Brain Injury |
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