Behavioral Deficits in Animal Models of Blast Traumatic Brain Injury

Blast exposure has been identified to be the most common cause for traumatic brain injury (TBI) in soldiers. Over the years, rodent models to mimic blast exposures and the behavioral outcomes observed in veterans have been developed extensively. However, blast tube design and varying experimental pa...

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Bibliographic Details
Published inFrontiers in neurology Vol. 11; p. 990
Main Authors Aravind, Aswati, Ravula, Arun Reddy, Chandra, Namas, Pfister, Bryan J.
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 04.09.2020
Subjects
anxiety and depression
auditory deficits
behavior deficits
blast TBI
cognitive deficits
motor deficits
Neurology
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Summary:Blast exposure has been identified to be the most common cause for traumatic brain injury (TBI) in soldiers. Over the years, rodent models to mimic blast exposures and the behavioral outcomes observed in veterans have been developed extensively. However, blast tube design and varying experimental parameters lead to inconsistencies in the behavioral outcomes reported across research laboratories. This review aims to curate the behavioral outcomes reported in rodent models of blast TBI using shockwave tubes or open field detonations between the years 2008–2019 and highlight the important experimental parameters that affect behavioral outcome. Further, we discuss the role of various design parameters of the blast tube that can affect the nature of blast exposure experienced by the rodents. Finally, we assess the most common behavioral tests done to measure cognitive, motor, anxiety, auditory, and fear conditioning deficits in blast TBI (bTBI) and discuss the advantages and disadvantages of these tests.
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Edited by: Denes V. Agoston, Karolinska Institutet (KI), Sweden
This article was submitted to Neurotrauma, a section of the journal Frontiers in Neurology
Reviewed by: Samar Abdelhady, Faculty of Medicine, Alexandria University, Egypt; Alana Conti, Wayne State University, United States
ISSN:1664-2295
1664-2295
DOI:10.3389/fneur.2020.00990