Use of antidepressant medications during pregnancy: a multisite study

• Published in: American journal of obstetrics and gynecology Vol. 198; no. 2; pp. 194.e1 - 194.e5
• Main Authors: Andrade, Susan E., ScD, Raebel, Marsha A., PharmD, Brown, Jeffrey, PhD, Lane, Kimberly, MPH, Livingston, James, MBA, Boudreau, Denise, PhD, Rolnick, Sharon J., PhD, Roblin, Douglas, PhD, Smith, David H., PhD, Willy, Mary E., MD, Staffa, Judy A., PhD, Platt, Richard, MD, MS
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Mosby, Inc 01.02.2008; Elsevier
• Subjects: Adolescent; Adult; antidepressant drugs; Antidepressive Agents - administration & dosage; Antidepressive Agents - therapeutic use; Biological and medical sciences; Databases, Factual; Depressive Disorder - drug therapy; Depressive Disorder - epidemiology; Drug Utilization Review; Female; Gynecology. Andrology. Obstetrics; Health Maintenance Organizations; Humans; Infant, Newborn; Medical sciences; Middle Aged; Obstetrics and Gynecology; Practice Patterns, Physicians' - statistics & numerical data; Pregnancy; Pregnancy Complications - drug therapy; Pregnancy Complications - epidemiology; Prenatal Care; Retrospective Studies; Serotonin Uptake Inhibitors - administration & dosage; Serotonin Uptake Inhibitors - therapeutic use; United States - epidemiology; United States; antidepressant drugs; pregnancy; Pregnancy; Drug; Treatment; Psychotropic; Gynecology; Use; Antidepressant agent; Female; Obstetrics
• ISSN: 0002-9378; 1097-6868
• DOI: 10.1016/j.ajog.2007.07.036

Objective This study was undertaken to provide information on the prevalence of use of antidepressant drugs among pregnant women in the United States. Study Design A retrospective study was conducted using the automated databases of 7 health plans. Women who delivered an infant in a hospital were identified. Antidepressant drug use was evaluated assuming a gestational duration of 270 days. Results Among the 118,935 deliveries occurring from 2001-2005, 6.6% of women were dispensed an antidepressant during pregnancy. Antidepressant drug use increased from 2.0% in 1996 to 7.6% of deliveries in 2004 and 2005. Selective serotonin reuptake inhibitor use increased from 1.5% in 1996 to 6.4% in 2004 and 6.2% in 2005. Conclusion Our finding that nearly 8% of pregnant women were prescribed antidepressants drugs during the years 2004 and 2005 highlights the importance of understanding the effects of these medications on the developing fetus and on the pregnant woman.