Mini-Review: Regenerating the Corneal Epithelium With Simple Limbal Epithelial Transplantation

• Published in: Frontiers in medicine Vol. 8; p. 673330
• Main Authors: Singh, Aastha, Sangwan, Virender S.
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 28.05.2021
• Subjects: corneal regeneration; limbal stem cell deficiency; limbal stem cell transplantation; limbal stem cells; Medicine; simple limbal epithelial transplantation
• ISSN: 2296-858X; 2296-858X
• DOI: 10.3389/fmed.2021.673330

Simple limbal epithelial transplantation (SLET) is an ingenious, low cost and effective technique of limbal stem cell transplantation (LSCT) that is increasingly being undertaken in practice across the world. Since it was first described a decade ago, the technique has been performed in a variety of cases of limbal stem cell deficiency (LSCD) and has underwent several innovative modifications. Published literature on SLET has progressively increased over time and successful outcomes in various clinical scenarios have been reported. This concise review attempts to present a crisp account of SLET covering the indications and contraindications of performing the procedure; detailed account of pre-operative work up and preparation; surgical technique and its modifications; post-operative course, care and possible complications as well as published outcomes of surgery from across the world. Comparative analysis of various techniques of LSCT have been discussed and common concerns of surgeons practising or those who are planning to start practising SLET have been addressed. The authors hope that the pragmatic insights and pearls given at the end of the review will aid the surgeons in performing this technique to provide maximum benefit to patients suffering from the potentially blinding condition of LSCD.