Altilix® Supplement Containing Chlorogenic Acid and Luteolin Improved Hepatic and Cardiometabolic Parameters in Subjects with Metabolic Syndrome: A 6 Month Randomized, Double-Blind, Placebo-Controlled Study

• Published in: Nutrients Vol. 11; no. 11; p. 2580
• Main Authors: Castellino, Giuseppa, Nikolic, Dragana, Magán-Fernández, Antonio, Malfa, Giuseppe Antonio, Chianetta, Roberta, Patti, Angelo M., Amato, Antonella, Montalto, Giuseppe, Toth, Peter P., Banach, Maciej, Cicero, Arrigo F. G., Rizzo, Manfredi
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.10.2019; MDPI
• Subjects: blood lipids; body weight; chlorogenic acid; Cytokines; Diabetes; Disease prevention; Double-blind studies; Enzymes; Fatty liver; Functional foods & nutraceuticals; Gastroenterology; Lipids; Liver diseases; luteolin; men; Metabolic syndrome; nutrition risk assessment; Obesity; Oxidative stress; placebos; Plasma; Substance abuse treatment; transaminases; ultrasonography; waist circumference; women; Womens health; United States > US; Italy; metabolic syndrome; non-alcoholic fatty liver disease; type 2; cynara; dietary supplements; diabetes mellitus; cardiovascular diseases
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu11112580

The objective was to evaluate the effects of 6 months of supplementation with Altilix®, containing chlorogenic acid and its derivatives, and luteolin and its derivatives, on cardiovascular risk and hepatic markers in subjects with metabolic syndrome (MetS). A randomized, double-blind, placebo-controlled study was performed in 100 subjects with MetS with a follow-up period of 6 months; 50 subjects were randomized to Altilix® (26 men and 24 women, mean age 63 ± 8 years) and the other 50 to placebo (28 men and 22 women, mean age 63 ± 11 years). Anthropometric, cardiometabolic, and hepatic parameters were assessed at baseline and at the end of follow-up. Carotid intima-media thickness and endothelial function were assessed by doppler ultrasound and by flow-mediated dilation of the brachial artery, respectively. The presence and degree of non-alcoholic fatty liver disease (NAFLD) was assessed by the fatty liver index (FLI), and subjects were divided into three subgroups: (1) without NAFLD; (2) with borderline NAFLD; and (3) with NAFLD. After 6 months of Altilix® supplementation, we found a significant improvement vs. placebo in most of the evaluated parameters, including body weight (−2.40% (95% CI −3.79, −1.01); p < 0.001), waist circumference (−2.76% (95% CI −4.55, −0.96); p = 0.003), HbA1c (−0.95% (95% CI −1.22, −0.67); p < 0.001), plasma lipids, FLI (−21.83% (95% CI −27.39, −16.27); p < 0.001), hepatic transaminases, flow-mediated dilation (10.56% (95% CI 5.00, 16.12); p < 0.001), and carotid intima-media thickness (−39.48% (95% CI −47.98, −30.97); p < 0.001). Further, the improvement in cardiometabolic variables was independent of the degree of hepatic steatosis. Altilix® supplementation improved hepatic and cardio-metabolic parameters in MetS subjects. Altilix® supplementation was a beneficial approach in the management of hepatic and cardiometabolic alterations in MetS subjects.