Circulating Vascular Cell Adhesion Molecule-1 (sVCAM-1) Is Associated With Left Atrial Remodeling in Long-Distance Runners
Introduction: An increased risk of atrial fibrillation (AF) has been demonstrated in high-performance athletes. Soluble vascular adhesion molecule-1 (sVCAM-1), a biomarker involved in inflammation and cardiac remodeling, is associated with the development of AF in the general population. However, th...
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Published in | Frontiers in cardiovascular medicine Vol. 8; p. 737285 |
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Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
01.11.2021
|
Subjects | |
Online Access | Get full text |
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Summary: | Introduction:
An increased risk of atrial fibrillation (AF) has been demonstrated in high-performance athletes. Soluble vascular adhesion molecule-1 (sVCAM-1), a biomarker involved in inflammation and cardiac remodeling, is associated with the development of AF in the general population. However, the relationship between sVCAM-1 and left atrial (LA) remodeling has been poorly investigated in long-distance runners (LDR).
Aim:
To determine the association between LA remodeling and sVCAM-1 levels in LDR during the training period before a marathon race.
Methods:
Thirty-six healthy male LDR (37.0 ± 5.3 years; 174.0 ± 7.0 height; BMI: 23.8 ± 2.8; V°O
2
-peak: 56.5 ± 7.3 mL·kg
−1
·min
−1
) were evaluated in this single-blind and cross-sectional study. The LDR were separated into two groups according to previous training levels: high-training (HT) (
n
= 18) ≥100 km·week
−1
and low-training (LT) (
n
= 18) ≥70 and <100 km·week
−1
. Also, 18 healthy non-active subjects were included as a control group (CTR). In all participants, transthoracic echocardiography was performed. sVCAM-1 blood levels were measured baseline and immediately finished the marathon race in LDR.
Results:
HT showed increased basal levels of sVCAM-1 (651 ± 350 vs. 440 ± 98 ng·mL
−1
CTR,
p
= 0.002; and vs. 533 ± 133 ng·mL
−1
LT;
p
= 0.003) and a post-marathon increase (ΔsVCAM-1) (651 ± 350 to 905 ± 373 ng·mL
−1
;
p
= 0.002), that did not occur in LT (533 ± 133 to 651 ± 138 ng·mL
−1
;
p
= 0.117). In LDR was a moderate correlation between LA volume and sVCAM-1 level (rho = 0.510;
p
= 0.001).
Conclusions:
In male long-distance runners, sVCAM-1 levels are directly associated with LA remodeling. Also, the training level is associated with basal sVCAM-1 levels and changes after an intense and prolonged exercise (42.2 km). Whether sVCAM-1 levels predict the risk of AF in runners remains to be established. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Pablo F. Castro orcid.org/0000-0002-9320-1703 Luigi Gabrielli orcid.org/0000-0002-1551-7147 This article was submitted to Cardiovascular Imaging, a section of the journal Frontiers in Cardiovascular Medicine Jorge E. Jalil orcid.org/0000-0001-6877-2072 Mario Chiong orcid.org/0000-0002-5174-6545 Julian Vega-Adauy orcid.org/0000-0002-4425-661X Edited by: Fabrizio Ricci, University of Studies G. d'Annunzio Chieti and Pescara, Italy Lorena García orcid.org/0000-0002-7775-5087 Sergio Lavandero orcid.org/0000-0003-4258-1483 Reviewed by: Alessandro Zorzi, University of Padua, Italy; Laura Ceriello, Azienda Usl Teramo, Italy ORCID: Felipe Contreras-Briceño orcid.org/0000-0002-0674-7506 María Paz Ocaranza orcid.org/0000-0002-4915-6378 |
ISSN: | 2297-055X 2297-055X |
DOI: | 10.3389/fcvm.2021.737285 |