Role of Nuclear Lamina in Gene Repression and Maintenance of Chromosome Architecture in the Nucleus

Nuclear lamina is a protein meshwork composed of lamins and lamin-associated proteins that lines the nuclear envelope from the inside and forms repressive transcription compartment. The review presents current data on the contribution of nuclear lamina to the repression of genes located in this comp...

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Bibliographic Details
Published inBiochemistry (Moscow) Vol. 83; no. 4; pp. 359 - 369
Main Authors Shevelyov, Y. Y., Ulianov, S. V.
Format Journal Article
LanguageEnglish
Published Moscow Pleiades Publishing 01.04.2018
Springer
Springer Nature B.V
Subjects
Biochemistry
Biomedical and Life Sciences
Biomedicine
Bioorganic Chemistry
Cell nucleus
Chromatin
Chromosomes
Gene expression
Gene silencing
Genetic aspects
Genetic research
Lamins
Life Sciences
Microbiology
Nuclear membrane
Nuclei
Physiological aspects
Proteins
Review
Structure
Transcription
lamina-associated domain
nuclear envelope
nuclear periphery
nuclear lamina
repression
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Summary:Nuclear lamina is a protein meshwork composed of lamins and lamin-associated proteins that lines the nuclear envelope from the inside and forms repressive transcription compartment. The review presents current data on the contribution of nuclear lamina to the repression of genes located in this compartment and on the mechanisms of chromatin attachment to the nuclear envelope.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0006-2979
1608-3040
DOI:10.1134/S0006297918040077