Acitretin induces capillary leak syndrome in a patient with pustular psoriasis

Capillary leak syndrome is a rare and potentially life-threatening condition caused by a shift of intravascular fluid and proteins to the interstitial space. We describe a patient with pustular psoriasis in whom capillary leak syndrome developed after the start of acitretin. Immediate withdrawal of...

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Bibliographic Details
Published inJournal of the American Academy of Dermatology Vol. 56; no. 2; pp. 339 - 342
Main Authors Vos, Lydia E., MD, PhD, Vermeer, Maarten H., MD, PhD, Pavel, Stan, MD, PhD
Format Journal Article
LanguageEnglish
Published New York, NY Mosby, Inc 01.02.2007
Elsevier
Subjects
Acitretin - adverse effects
Acitretin - therapeutic use
Aged
Biological and medical sciences
Bullous diseases of the skin
Capillary Leak Syndrome - chemically induced
Capillary Leak Syndrome - complications
Capillary Leak Syndrome - physiopathology
Dermatology
Dyspnea - etiology
Edema - etiology
Female
Humans
Keratolytic Agents - adverse effects
Keratolytic Agents - therapeutic use
Medical sciences
Psoriasis - drug therapy
Vascular disease
Human
Skin disease
Acitretin
Pustular psoriasis
Dermatology
Pustulosis dermatosis
Capillary leak syndrome
Retinoid
Cardiovascular disease
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Summary:Capillary leak syndrome is a rare and potentially life-threatening condition caused by a shift of intravascular fluid and proteins to the interstitial space. We describe a patient with pustular psoriasis in whom capillary leak syndrome developed after the start of acitretin. Immediate withdrawal of retinoic acid is necessary and corticosteroid therapy should be considered.
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2006.08.006