P1245 Polymorphic Variants of HSD3B1 Gene Confer Different Outcome in Specific Subgroups of Patients Infected With SARS-CoV-2
Introduction: Severe respiratory syndrome coronavirus 2 (SARS-CoV-2) uses the androgen receptor (AR), through ACE2 receptor and TMPRSS2, to enter nasal and upper airways epithelial cells. Genetic analyses revealed that HSD3B1 P1245C polymorphic variant increases dihydrotestosterone production and up...
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Published in | Frontiers in medicine Vol. 8; p. 793728 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
07.07.2022
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Subjects | |
Online Access | Get full text |
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Summary: | Introduction:
Severe respiratory syndrome coronavirus 2 (SARS-CoV-2) uses the androgen receptor (AR), through ACE2 receptor and TMPRSS2, to enter nasal and upper airways epithelial cells. Genetic analyses revealed that
HSD3B1
P1245C polymorphic variant increases dihydrotestosterone production and upregulation of TMPRSS2 with respect to P1245A variant, thus possibly influencing SARS-CoV-2 infection. Our aim was to characterize the
HSD3B1
polymorphism status and its potential association with clinical outcomes in hospitalized patients with COVID-19 in Southern Switzerland.
Materials and Methods:
The cohort included 400 patients hospitalized for COVID-19 during the first wave between February and May 2020 in two different hospitals of Canton Ticino. Genomic DNA was extracted from formalin-fixed paraffin-embedded tissue blocks, and
HSD3B1
gene polymorphism was evaluated by Sanger sequencing. Statistical associations were verified using different test.
Results:
HSD3B1
polymorphic variants were not associated with a single classical factor related to worse clinical prognosis in hospitalized patients with SARS-CoV-2. However, in specific subgroups,
HSD3B1
variants played a clinical role: intensive care unit admission was more probable in patients with P1245C diabetes compared with P1245A individuals without this comorbidity and death was more associated with hypertensive P1245A>C cases than patients with P1245A diabetes without hypertension.
Discussion:
This is the first study showing that
HSD3B1
gene status may influence the severity of SARS-CoV-2 infection. If confirmed, our results could lead to the introduction of
HSD3B1
gene status analysis in patients infected with SARS-CoV-2 to predict clinical outcome. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Hamid Asadzadeh, Shahid Beheshti University of Medical Sciences, Iran; Timothée Bruel, Institut Pasteur, France This article was submitted to Infectious Diseases - Surveillance, Prevention and Treatment, a section of the journal Frontiers in Medicine These authors have contributed equally to this work and share first authorship These authors have contributed equally to this work and share last authorship Edited by: Andy Goren, Applied Biology, Inc., United States |
ISSN: | 2296-858X 2296-858X |
DOI: | 10.3389/fmed.2021.793728 |