Inhibition of Human Immunodeficiency Virus Type 1 Assembly and Release by the Cholesterol-Binding Compound Amphotericin B Methyl Ester: Evidence for Vpu Dependence

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Published inJournal of Virology Vol. 82; no. 19; pp. 9776 - 9781
Main Authors WAHEED, Abdul A, ABLAN, Sherimay D, SOHEILIAN, Ferri, NAGASHIMA, Kunio, ONO, Akira, SCHAFFNER, Carl P, FREED, Eric O
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.10.2008
American Society for Microbiology (ASM)
Subjects
Amphotericin B - analogs & derivatives
Amphotericin B - pharmacology
Antigens, CD - chemistry
Biological and medical sciences
Cell Membrane - metabolism
Cell Membrane - virology
Cholesterol - metabolism
Fundamental and applied biological sciences. Psychology
Gene Products, gag - metabolism
GPI-Linked Proteins
HeLa Cells
HIV-1 - metabolism
Human Immunodeficiency Virus Proteins - metabolism
Humans
Membrane Glycoproteins - chemistry
Membrane Microdomains - chemistry
Microbiology
Miscellaneous
Protein Binding
Protein Structure, Tertiary
Structure and Assembly
Transfection
Viral Regulatory and Accessory Proteins - metabolism
Virology
Immunopathology
HIV-1 virus
Retroviridae
AIDS
Immune deficiency
Lentivirus
Cholesterol
Virology
Infection
Virus
Antiprotozoal agent
Antibiotic
Antifungal agent
Amphotericin B
Viral disease
Dependence
Parasiticide
Human immunodeficiency virus
Release
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content type line 23
Corresponding author. Mailing address: Virus-Cell Interaction Section, HIV Drug Resistance Program, NCI-Frederick, Bldg. 535, Rm. 108, Frederick, MD 21702-1201. Phone: (301) 846-1739. Fax: (301) 846-6777. E-mail: awaheed@ncifcrf.gov
Present address: Department of Microbiology and Immunology, University of Michigan Medical School, 6706 Medical Science Building II, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0620.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.00917-08