Hyperhomocysteinemia as risk factor for ischemic and hemorrhagic stroke in newborn infants

• Published in: The Journal of pediatrics Vol. 141; no. 3; pp. 429 - 431
• Main Authors: Hogeveen, Marije, Blom, Henk J., van Amerongen, Marjolein, Boogmans, Bas, van Beynum, Ingrid M., van de Bor, Margot
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.09.2002; Elsevier
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Brain Ischemia - epidemiology; Brain Ischemia - etiology; Cerebral Hemorrhage - epidemiology; Cerebral Hemorrhage - etiology; Emergency and intensive care: neonates and children. Prematurity. Sudden death; Humans; Hyperhomocysteinemia - complications; Infant, Newborn; Intensive care medicine; Logistic Models; Medical sciences; Netherlands - epidemiology; Retrospective Studies; Risk Factors; Stroke - epidemiology; Stroke - etiology; Netherlands; OR; tHcy; Human; Nervous system diseases; Cardiovascular disease; Metabolic diseases; Epidemiology; Cerebral disorder; Vascular disease; Newborn diseases; Newborn; Ischemia; Cerebral hemorrhage; Central nervous system disease; Risk factor; Hyperhomocysteinemia; Cerebrovascular disease; Brain (vertebrata)
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1067/mpd.2002.126598

We studied the association between plasma total homocysteine concentrations and the occurrence of stroke in newborn infants (n = 24). Newborn infants with stroke had significantly higher mean total homocysteine concentrations compared with 94 healthy newborn infants (9.3 vs 7.4 μmol/L). The odds ratio for neonatal stroke was 3.95 (95” CI 1.53-10.16) at the 80” cutoff level. (J Pediatr 2002;141:429-31)