Methotrexate clearance by high-flux hemodialysis and peritoneal dialysis: a case report

• Published in: American journal of kidney diseases Vol. 53; no. 5; p. 871
• Main Authors: Murashima, Miho, Adamski, Jill, Milone, Michael C, Shaw, Leslie, Tsai, Donald E, Bloom, Roy D
• Format: Journal Article
• Language: English
• Published: United States 01.05.2009
• Subjects: Dialysis Solutions - analysis; Follow-Up Studies; Humans; Immunosuppressive Agents - pharmacokinetics; Immunosuppressive Agents - therapeutic use; Kidney Failure, Chronic - complications; Kidney Failure, Chronic - metabolism; Kidney Failure, Chronic - therapy; Lymphoma, Large B-Cell, Diffuse - complications; Lymphoma, Large B-Cell, Diffuse - drug therapy; Lymphoma, Large B-Cell, Diffuse - metabolism; Male; Metabolic Clearance Rate; Methotrexate - pharmacokinetics; Methotrexate - therapeutic use; Middle Aged; Peritoneal Dialysis - methods
• ISSN: 1523-6838
• DOI: 10.1053/j.ajkd.2009.01.016

We report a case of a patient on maintenance peritoneal dialysis therapy treated with a high-dose methotrexate regimen for central nervous system lymphoma. For the initial methotrexate cycles, he had received temporary daily high-flux hemodialysis starting 24 hours after the infusion of methotrexate to avoid toxicity. However, on account of issues with vascular access, he was treated with continuous multiple-exchange peritoneal dialysis for the last 2 cycles of chemotherapy. Time-averaged clearances (dose divided by area under the curve, combination of endogenous and dialysis clearance) during treatment with high-flux hemodialysis and continuous multiple-exchange peritoneal dialysis were 0.77 mL/min/kg (0.013 mL/s/kg) and 0.65 mL/min/kg (0.011 mL/s/kg), respectively. Peritoneal clearance of methotrexate was estimated to be 0.124 +/- 0.037 mL/min/kg (0.00207 +/- 0.00062 mL/s/kg). Despite lower clearance by means of peritoneal dialysis compared with hemodialysis, the patient did not develop clinical evidence of methotrexate toxicity.