Immunotherapy: The meta-analyses. What have we Learned?

Meta-analysis is a powerful tool for evaluating the efficacy of a therapeutic intervention, and has clearly demonstrated that specific allergen immunotherapy (SIT) is effective for treating allergic rhinitis and asthma. Future research needs to focus on specifying the most effective forms of SIT for...

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Bibliographic Details
Published inImmunology and allergy clinics of North America Vol. 31; no. 2; p. 159
Main Authors Calderón, Moisés A, Boyle, Robert J, Penagos, Martin, Sheikh, Aziz
Format Journal Article
LanguageEnglish
Published United States 01.05.2011
Subjects
Administration, Cutaneous
Administration, Sublingual
Allergens - immunology
Allergens - therapeutic use
Desensitization, Immunologic
Humans
Hypersensitivity - immunology
Hypersensitivity - therapy
Treatment Outcome
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Summary:Meta-analysis is a powerful tool for evaluating the efficacy of a therapeutic intervention, and has clearly demonstrated that specific allergen immunotherapy (SIT) is effective for treating allergic rhinitis and asthma. Future research needs to focus on specifying the most effective forms of SIT for specific populations and allergens, using validated clinical outcomes, studying long-term outcomes (particularly the potential disease-modifying effect of immunotherapy), and assessing outcomes regarding health economics. The safety profile of SIT should be evaluated using international guidelines and terminology, and needs to include high-quality surveillance data.
ISSN:1557-8607
DOI:10.1016/j.iac.2011.02.002