Preanalytical Variables in Coagulation Testing: Setting the Stage for Accurate Results

Abstract Many preanalytical variables may affect the results of routine coagulation assays. While advances in laboratory instrumentation have partially addressed the laboratory's ability to recognize some of these variables, there remains an increased reliance on laboratory personnel to recogni...

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Bibliographic Details
Published inSeminars in thrombosis and hemostasis Vol. 45; no. 5; pp. 433 - 448
Main Authors Gosselin, Robert C., Marlar, Richard A.
Format Journal Article
LanguageEnglish
Published 333 Seventh Avenue, New York, NY 10001, USA Thieme Medical Publishers 01.07.2019
Subjects
Blood Coagulation Tests - methods
Blood Preservation - methods
Humans
Review Article
specimens
preanalytical variables
coagulation testing
recommendations
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Summary:Abstract Many preanalytical variables may affect the results of routine coagulation assays. While advances in laboratory instrumentation have partially addressed the laboratory's ability to recognize some of these variables, there remains an increased reliance on laboratory personnel to recognize the three potential areas where coagulation testing preanalytical issues may arise: (1) specimen collection (including patient selection), (2) specimen transportation and stability, and (3) specimen processing and storage. The purpose of this article is to identify the preanalytical variables associated with coagulation-related testing and provide laboratory practice recommendations in an effort to improve the quality of coagulation testing and accuracy of result reporting.
ISSN:0094-6176
1098-9064
DOI:10.1055/s-0039-1692700