Role of m6A Methylation in the Occurrence and Development of Heart Failure

• Published in: Frontiers in cardiovascular medicine Vol. 9; p. 892113
• Main Authors: Fan, Shaowei, Hu, Yuanhui
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 24.06.2022
• Subjects: autophagy; calcium homeostasis; cardiovascular disease; Cardiovascular Medicine; heart failure; m6A methylation
• ISSN: 2297-055X; 2297-055X
• DOI: 10.3389/fcvm.2022.892113

N6-methyladenosine (m6A) RNA methylation is one of the most common epigenetic modifications in RNA nucleotides. It is known that m6A methylation is involved in regulation, including gene expression, homeostasis, mRNA stability and other biological processes, affecting metabolism and a variety of biochemical regulation processes, and affecting the occurrence and development of a variety of diseases. Cardiovascular disease has high morbidity, disability rate and mortality in the world, of which heart failure is the final stage. Deeper understanding of the potential molecular mechanism of heart failure and exploring more effective treatment strategies will bring good news to the sick population. At present, m6A methylation is the latest research direction, which reveals some potential links between epigenetics and pathogenesis of heart failure. And m6A methylation will bring new directions and ideas for the prevention, diagnosis and treatment of heart failure. The purpose of this paper is to review the physiological and pathological mechanisms of m6A methylation that may be involved in cardiac remodeling in heart failure, so as to explain the possible role of m6A methylation in the occurrence and development of heart failure. And we hope to help m6A methylation obtain more in-depth research in the occurrence and development of heart failure.