Functional chromopeptide nanoarchitectonics: molecular design, self-assembly and biological applications
Chromoproteins are a class of delicate natural compounds that elegantly complex photosensitive species with proteins and play a central role in important life processes, such as photosynthesis. Inspired by chromoproteins, researchers integrate simple peptides and photosensitive molecular motifs to g...
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| Published in | Chemical Society reviews Vol. 52; no. 8; pp. 2688 - 2712 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Royal Society of Chemistry
24.04.2023
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| Subjects | |
| Online Access | Get full text |
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| Summary: | Chromoproteins are a class of delicate natural compounds that elegantly complex photosensitive species with proteins and play a central role in important life processes, such as photosynthesis. Inspired by chromoproteins, researchers integrate simple peptides and photosensitive molecular motifs to generate chromopeptides. Compared with chromoproteins, chromopeptides exhibit a relatively simple molecular structure, flexible and adjustable photophysical properties, and a capability of programmable self-assembly. Chromopeptide self-assembly has attracted great attention as the resultant high-level architectures exhibit an ingenious combination of photofunctions and biofunctions. This review systematically summarizes recent advances in chromopeptide nanoarchitectonics with particular focus on the design strategy, assembly mechanism, and structure-function relationship. Among them, the effect of peptide sequences and the variation in photophysical performance are critically emphasized. On this basis, various applications, including biomedicine and artificial photosynthesis, are discussed together with the future prospects of chromopeptide nanoarchitectonics. This review will provide insights into chromopeptide nanoarchitectonics and corresponding materials with precise designs, flexible nanostructures and versatile functions. In addition, knowledge involving chromopeptide nanoarchitectonics may aid in the development of many other kinds of supramolecular biological materials and bioengineering techniques.
An overview of chromopeptide self-assembly is presented to systematically understand this kind of newly emerging peptide building block. |
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| Bibliography: | Rui Chang received her PhD degree from the Institute of Process Engineering (IPE), University of Chinese Academy of Sciences (UCAS), in 2022; then she started post-doctoral research at the Institute of Process Engineering (IPE), Chinese Academy of Sciences (CAS), under the supervision of Prof. Yan in the same year. Her research interests are mainly focused on peptide-based nanodrugs and their application in the area of antitumor theranostics, especially phototherapy and immunotherapy. Xuehai Yan is a full professor at the Institute of Process Engineering, Chinese Academy of Sciences (CAS). Currently, he is the deputy director of the State Key Laboratory of Biochemical Engineering and the Center of Mesoscience, IPE, CAS. His research interests are focused on peptide self-assembly and engineering, supramolecular colloids and crystals, phase evolution and dynamic transition, as well as cancer phototherapy and immunotherapy. Junbai Li is a professor at the Institute of Chemistry in the Chinese Academy of Sciences. His research interests include molecular biomimetics based on molecular assembly, reconstitution of motor proteins, self-assembly of dipeptides, biointerfaces, bioinspired materials, and nanostructure design. Ruirui Xing is currently an associate professor at the Institute of Process Engineering (IPE), CAS. Her research interests are focused on the design and self-assembly of functional peptides, supramolecular effects, nanomaterials and nanodrugs, and applications in the field of biomedicine. Luyang Zhao received his PhD degree in chemistry in 2016 from the University of Science and Technology Beijing. He then joined Prof. Xuehai Yan's group as a postdoc at the State Key Laboratory of Biochemical Engineering, IPE, CAS, and became an associated professor in 2019. His research interests are focused on the design of peptide-based bioactive molecules and self-assembling photosensitive materials. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ISSN: | 0306-0012 1460-4744 1460-4744 |
| DOI: | 10.1039/d2cs00675h |