Stereochemical Effects in Mass Spectrometry - Determination of the Optical Purity of Enantiomers by Mass Spectrometry

Due to the difference in reactivity of enantiomers with chiral reagents, it was found that in the Fast Atom Bombardment (FAB) mass spectra of enantiomer mixtures of R-α-phenylethylamine and S-α-phenylethylamine with a chiral reagent S-phosphorsaeure-(1,1′-bi-naphthyl-2,2′-diylester) (BNP acid), the...

Full description

Saved in:
Bibliographic Details
Published inAnalytical letters Vol. 30; no. 7; pp. 1399 - 1406
Main Authors Wu, Yi-Nan, Tu, Ya-Ping, Pan, Yuan-Jiang, Chen, Yao-Zu, Cui, Meng, Song, Feng-Rui, Liu, Shu-Ying
Format Journal Article
LanguageEnglish
Published Philadelphia, PA Taylor & Francis Group 01.05.1997
Taylor & Francis
Subjects
Analytical chemistry
Chemistry
enantiomers
Exact sciences and technology
mass spectrometric determination
optical purity
R-α-phenylethylamine
S-α-phenylethylamine
Spectrometric and optical methods
Stereoisomer
Amine
Steric effect
Multicomponent mixture
Enantiomer
Purity control
Optical purity
Mass spectrometry
Quantitative analysis
Online AccessGet full text

Cover

More Information
Summary:Due to the difference in reactivity of enantiomers with chiral reagents, it was found that in the Fast Atom Bombardment (FAB) mass spectra of enantiomer mixtures of R-α-phenylethylamine and S-α-phenylethylamine with a chiral reagent S-phosphorsaeure-(1,1′-bi-naphthyl-2,2′-diylester) (BNP acid), the relative abundance of the characteristic ion is linearly related to the composition of the mixture. We have, therefore, proposed a possible method for the determination of the optical purity of enantiomers by mass spectrometry.
ISSN:0003-2719
1532-236X
DOI:10.1080/00032719708007225