Mitochondrial Quality Control in Hepatocellular Carcinoma

Mitochondria participate in the progression of hepatocellular carcinoma (HCC) by modifying processes including but not limited to redox homeostasis, metabolism, and the cell death pathway. These processes depend on the health status of the mitochondria. Quality control processes in mitochondria can...

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Published inFrontiers in oncology Vol. 11; p. 713721
Main Authors Bian, Jinda, Zhang, Dan, Wang, Yicun, Qin, Hanjiao, Yang, Wei, Cui, Ranji, Sheng, Jiyao
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 13.09.2021
Subjects
chemoresistance
hepatocellular carcinoma
mitochondrial quality control
Oncology
tumor progression
tumorigenesis
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Summary:Mitochondria participate in the progression of hepatocellular carcinoma (HCC) by modifying processes including but not limited to redox homeostasis, metabolism, and the cell death pathway. These processes depend on the health status of the mitochondria. Quality control processes in mitochondria can repair or eliminate “unhealthy mitochondria” at the molecular, organelle, or cellular level and form an efficient integrated network that plays an important role in HCC tumorigenesis, patient survival, and tumor progression. Here, we review the influence of mitochondria on the biological behavior of HCC. Based on this information, we further highlight the need for determining the role and mechanism of interaction between different levels of mitochondrial quality control in regulating HCC occurrence and progression as well as resistance development. This information may lead to the development of precision medicine approaches against targets involved in various mitochondrial quality control-related pathways.
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Edited by: Xing-Xing He, Huazhong University of Science and Technology, China
These authors have contributed equally to this work and share first authorship
This article was submitted to Gastrointestinal Cancers, a section of the journal Frontiers in Oncology
Reviewed by: Wei Liu, Sun Yat-sen University, China; Ke Chen, Huazhong University of Science and Technology, China
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2021.713721