Determinants of Aortic Pressure Variation During Positive-Pressure Ventilation in Man

• Published in: Chest Vol. 116; no. 1; pp. 176 - 186
• Main Authors: Denault, André Y., Gasior, Thomas A., Gorcsan, John, Mandarino, William A., Deneault, Lee G., Pinsky, Michael R.
• Format: Journal Article
• Language: English
• Published: Northbrook, IL Elsevier Inc 01.07.1999; American College of Chest Physicians
• Subjects: Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Aorta - physiology; Biological and medical sciences; Blood Pressure - physiology; cardiovascular function; Coronary Artery Bypass; Echocardiography, Transesophageal; Emergency and intensive respiratory care; heart-lung interactions; hemodynamic monitoring; Hemodynamics; Hemodynamics - physiology; Humans; Intensive care medicine; Medical sciences; Positive-Pressure Respiration; Postoperative Period; Pulmonary arteries; pulsus paradoxus; Systole - physiology; Ventricular Function, Left - physiology; Δup; ABD; EDA; SAP; IABP; ITP; heart-lung interactions; Ppao; LV; Δdown; hemodynamic monitoring; SA; pulsus paradoxus; 2D; ESA; TEE; cardiovascular function; Vt; Cardiopulmonary bypass; Heart; Human; Positive pressure; Functional response; Surgery; Evolution; Exploration; Arterial pressure; Hemodynamics; Left ventricle performance
• ISSN: 0012-3692; 1931-3543
• DOI: 10.1378/chest.116.1.176

To define the relation between systolic arterial pressure (SAP) changes during ventilation and left ventricular (LV) performance in humans. Prospective repeat-measures series. University of Pittsburgh Medical Center Operating Room. Fifteen anesthetized cardiac surgery patients before and after cardiopulmonary bypass when the mediastinum was either closed or open. Positive-pressure ventilation. SAP and LV midaxis cross-sectional areas were measured during apnea and then were measured for three consecutive breaths. SAP increased during inspiration, this being the greatest during closed chest conditions (p < 0.05). Changes in SAP could not be correlated with changes in either LV end-diastolic areas (EDAs), end-systolic areas, or stroke areas (SAs). If SAP decreased relative to apnea, the decrease occurred during expiration and was often associated with increasing LV EDAs and SAs. SAP often decreased after a positive-pressure breath, but the decrease was unrelated to SA deficits during the breath. Increases in SAP were in phase with increases in airway pressure, whereas decreases in SAP, if present, followed inspiration. No consistent relation between SAP variation and LV area could be identified. In this patient group, changes in SAP reflect changes in airway pressure and (by inference) intrathoracic pressure (as in a Valsalva maneuver) better than they reflect concomitant changes in LV hemodynamics.