The effect of Platycodin D on the expression of cytoadherence proteins P1 and P30 in Mycoplasma pneumoniae models

• Published in: Environmental toxicology and pharmacology Vol. 49; pp. 188 - 193
• Main Authors: Meng, Yan-li, Wang, Wei-ming, Lv, Dan-dan, An, Qiu-xia, Lu, Wei-hong, Wang, Xin, Tang, Guixin
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 2017; Elsevier Science Ltd
• Subjects: A549 Cells; Adhesins, Bacterial - genetics; Adhesion; Animal models; Animals; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - therapeutic use; Cell adhesion & migration; Emergency; Herbal medicine; Humans; M. pneumoniae; Mice, Inbred BALB C; Minimum inhibitory concentration; Monomers; Mycoplasma pneumoniae; Mycoplasma pneumoniae - drug effects; Mycoplasma pneumoniae - genetics; Mycoplasma pneumoniae - pathogenicity; P30; Pharmacodynamics; Pharmacology; Platycodin D; Pneumonia; Pneumonia, Mycoplasma - prevention & control; Proteins; Reverse transcription; RNA, Messenger - metabolism; Saponins - pharmacology; Saponins - therapeutic use; Traditional Chinese medicine; Triterpenes - pharmacology; Triterpenes - therapeutic use; P1; Animal models; M. pneumoniae; P30; Platycodin D
• ISSN: 1382-6689; 1872-7077
• DOI: 10.1016/j.etap.2017.01.001

Highlights • Platycodin D is one of the most important monomers of the Qinbaiqingfei pellet (Qinbai), which has already been approved as the first effective new Traditional Chinese Medicine used to fight against Mycoplasma pneumoniae ( M. pneumoniae ) in clinic in China. • Platycodin D strongly inhibited P1 and P30 expression in M. pneumonia and high dosage of Platycodin D exhibited a greater effect on reducing P1 and P30 expression than low dose Platycodin D. • Platycodin D prevented M. pneumoniae infection through inhibiting the expression of adhesion proteins, which might be one of the mechanisms for the anti-M. pneumoniae properties of Qinbai.