Modeling immunity in microphysiological systems

There is a need for better predictive models of the human immune system to evaluate safety and efficacy of immunomodulatory drugs and biologics for successful product development and regulatory approvals. Current in vitro models, which are often tested in two-dimensional (2D) tissue culture polystyr...

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Bibliographic Details
Published inExperimental Biology and Medicine Vol. 248; no. 22; pp. 2001 - 2019
Main Authors Kwee, Brian J, Li, Xiaoqing, Nguyen, Xinh-Xinh, Campagna, Courtney, Lam, Johnny, Sung, Kyung E
Format Book Review Journal Article
LanguageEnglish
Published London, England SAGE Publications 01.11.2023
Subjects
Animals
Humans
Immunotherapy
Microphysiological Systems
Minireview
Tumor Microenvironment
tissue interfaces
inflammatory diseases
Microphysiological systems
immunity
tumor microenvironment
lymphatics
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Summary:There is a need for better predictive models of the human immune system to evaluate safety and efficacy of immunomodulatory drugs and biologics for successful product development and regulatory approvals. Current in vitro models, which are often tested in two-dimensional (2D) tissue culture polystyrene, and preclinical animal models fail to fully recapitulate the function and physiology of the human immune system. Microphysiological systems (MPSs) that can model key microenvironment cues of the human immune system, as well as of specific organs and tissues, may be able to recapitulate specific features of the in vivo inflammatory response. This minireview provides an overview of MPS for modeling lymphatic tissues, immunity at tissue interfaces, inflammatory diseases, and the inflammatory tumor microenvironment in vitro and ex vivo. Broadly, these systems have utility in modeling how certain immunotherapies function in vivo, how dysfunctional immune responses can propagate diseases, and how our immune system can combat pathogens.
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These authors contributed equally to this paper.
ISSN:1535-3702
1535-3699
1535-3699
DOI:10.1177/15353702231215897