Erythema multiforme major and disseminated intravascular coagulation in a dog following application of a d-limonene-based insecticidal dip
Erythema multiforme major and disseminated intravascular coagulation developed in a dog 24 hours after exposure to a d-limonene-based insecticidal dip. Clinical signs included severe lethargy and weakness, ulceration of the oral mucosa, and erythematous serpiginous, annular, and arciform lesions on...
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Published in | Journal of the American Veterinary Medical Association Vol. 207; no. 10; p. 1315 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
15.11.1995
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Subjects | |
Online Access | Get more information |
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Summary: | Erythema multiforme major and disseminated intravascular coagulation developed in a dog 24 hours after exposure to a d-limonene-based insecticidal dip. Clinical signs included severe lethargy and weakness, ulceration of the oral mucosa, and erythematous serpiginous, annular, and arciform lesions on the head, trunk, and limbs. Clinicopathologic abnormalities included leukocytosis with neutrophilia, normocytic normochromic anemia, thrombocytopenia, prolongation of prothrombin and partial thromboplastin times, increased fibrin degradation products, hypoproteinemia, hyponatremia, hypochloremia, azotemia, high serum alanine aminotransferase and alkaline phosphatase activities, and high serum bilirubin concentration. Despite intensive supportive care, the dog developed severe intrathoracic and abdominal hemorrhage and died. Necropsy revealed severe diffuse epidermal necrosis and widespread hemorrhage within organs. Insecticidal dips containing d-limonene have the potential to induce various toxic effects, including, possibly, erythema multiforme major, and should be used cautiously. |
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Bibliography: | L70 9566540 |
ISSN: | 0003-1488 1943-569X |
DOI: | 10.2460/javma.1995.207.10.1315 |