Antileishmanial in vitro activity of essential oil from Myrciaria plinioides, a native species from Southern Brazil

In South American folk medicine members of the genus Myrciaria are used for the treatment of malaria, diarrhoea, asthma, inflammation and post-partum uterine cleansing. The aim of this work was to evaluate its antileishmanial properties (in vitro) of essential oil derived from leaves of Myrciaria pl...

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Bibliographic Details
Published inBrazilian Journal of Pharmaceutical Sciences Vol. 55
Main Authors Kauffmann, Carla, Giacomin, Ana Caroline, Arossi, Kelen, Pacheco, Leandra Andressa, Hoehne, Lucélia, Freitas, Elisete Maria de, Machado, Gérzia Maria de Carvalho, Cavalheiro, Marilene Marcuzzo do Canto, Gnoatto, Simone Cristina Baggio, Ethur, Eduardo Miranda
Format Journal Article
LanguageEnglish
Portuguese
Published Sao Paulo Universidade de Sao Paulo Faculdade de Ciencias 01.01.2019
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
Universidade de São Paulo
Subjects
Analytical chemistry
Antileishmanial activity
Insects
Leishmania amazonensis
Leishmania infantum
Myrciaria plinioides
Myrtaceae
Oils & fats
Parasitic diseases
PHARMACOLOGY & PHARMACY
Tropical diseases
Brazil
Myrtaceae
Leishmania infantum
Myrciaria plinioides
Antileishmanial activity
Leishmania amazonensis
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Summary:In South American folk medicine members of the genus Myrciaria are used for the treatment of malaria, diarrhoea, asthma, inflammation and post-partum uterine cleansing. The aim of this work was to evaluate its antileishmanial properties (in vitro) of essential oil derived from leaves of Myrciaria plinioides D. Legrand, a plant species that is native in South of Brazil. The essential oil was obtained by hydro-distillation using fresh leaves of M. plinioides. The chemical composition of this essential oil (MPEO, M. plinioides essential oil) was determined by gas chromatography coupled to mass spectrometry (GC-MS). MPEO was assayed in vitro for antileishmanial properties against promastigotes of Leishmania amazonensis and Leishmania infantum, and for cytotoxicity against murine peritoneal macrophages. The MPEO comprised 66 components and was rich in oxygenated sesquiterpenes (82.66%) containing spathulenol (21.12%) as its major constituent. The MPEO was effective against L. amazonensis with IC50 value of 14.16 ± 7.40 µg/mL, while against L. infantum the IC50 value was higher with 101.50 ± 5.78 µg/mL. The MPEO showed significant activity against L. amazonensis, and presented a selectivity index (SI) of 6.60. The results suggest that the essential oil from leaves of M. plinioides is a promising source for new antileishmanial agents against L. amazonensis.
ISSN:2175-9790
1984-8250
2175-9790
DOI:10.1590/s2175-97902019000217584