Fumonisin B1-Induced Toxicity Was Not Exacerbated in Glutathione Peroxidase-1/Catalase Double Knock Out Mice

• Published in: Biomolecules & therapeutics Vol. 29; no. 1; pp. 52 - 57
• Main Authors: Yayeh, Taddesse, Jeong, Ha Ram, Park, Yoon Soo, Moon, Sohyeon, Sur, Bongjun, Yoo, Hwan-Soo, Oh, Seikwan
• Format: Journal Article
• Language: English
• Published: Korea (South) The Korean Society of Applied Pharmacology 01.01.2021; 한국응용약물학회
• Subjects: Original; 약학; Fumonisin B1; Catalase; Glutathione peroxidase1; Sphinganine; Sphingosine

Fumonisin B1 (FB1) structurally resembles sphingolipids and interferes with their metabolism leading to sphingolipid dysregulation. We questioned if FB1 could exacerbate liver or kidney toxicities in glutathione peroxidase 1 (Gpx1) and catalase (Cat) knockout mice. While higher serum levels of thiob...