Fumonisin B1-Induced Toxicity Was Not Exacerbated in Glutathione Peroxidase-1/Catalase Double Knock Out Mice

Fumonisin B1 (FB1) structurally resembles sphingolipids and interferes with their metabolism leading to sphingolipid dysregulation. We questioned if FB1 could exacerbate liver or kidney toxicities in glutathione peroxidase 1 (Gpx1) and catalase (Cat) knockout mice. While higher serum levels of thiob...

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Published inBiomolecules & therapeutics Vol. 29; no. 1; pp. 52 - 57
Main Authors Yayeh, Taddesse, Jeong, Ha Ram, Park, Yoon Soo, Moon, Sohyeon, Sur, Bongjun, Yoo, Hwan-Soo, Oh, Seikwan
Format Journal Article
LanguageEnglish
Published Korea (South) The Korean Society of Applied Pharmacology 01.01.2021
한국응용약물학회
Subjects
Original
약학
Fumonisin B1
Catalase
Glutathione peroxidase1
Sphinganine
Sphingosine
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Summary:Fumonisin B1 (FB1) structurally resembles sphingolipids and interferes with their metabolism leading to sphingolipid dysregulation. We questioned if FB1 could exacerbate liver or kidney toxicities in glutathione peroxidase 1 (Gpx1) and catalase (Cat) knockout mice. While higher serum levels of thiobarbituric acid reactive substances (TBARS) and sphinganine ( ) were measured in Gpx1/Cat knockout mice (Gpx1/Cat KO) than wild type mice after 5 days of FB1 treatment, serum levels of alanine aminotransferase (ALT), sphingosine-1 phosphate ( ), and sphinganine-1 phosphate ( ) were found to be relatively low. Although was highly elevated in Gpx1/Cat KO mice and wild mice, lower levels of and were found in both the kidney and liver tissues of Gpx/Cat KO mice than wild type mice after FB1 treatment. Paradoxically, FB1-induced cellular apoptosis and necrosis were hastened under oxidative stress in Gpx1/Cat KO mice.
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ISSN:1976-9148
2005-4483
DOI:10.4062/biomolther.2020.062