The Identification of Necroptosis-Related Subtypes, the Construction of a Prognostic Model, and the Characterization of the Tumor Microenvironment in Gliomas

Necroptosis is a recently discovered form of cell death that plays a vital role in the progression of cancer, the spread of metastases, and the immunologic response to tumors. Due to the dual role of necrotic apoptotic processes in tumor pathogenesis and the heterogeneity of gliomas, the function of...

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Published inFrontiers in oncology Vol. 12; p. 899443
Main Authors Ba, Yueyang, Su, Jiahao, Gao, Shuangqi, Liao, Zhi, Wu, Zhimin, Cao, Chengan, Liang, Chaofeng, Gong, Jin, Guo, Ying
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 02.06.2022
Subjects
glioma
necroptosis
nomogram
Oncology
TMB
tumor microenvironment
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Summary:Necroptosis is a recently discovered form of cell death that plays a vital role in the progression of cancer, the spread of metastases, and the immunologic response to tumors. Due to the dual role of necrotic apoptotic processes in tumor pathogenesis and the heterogeneity of gliomas, the function of necroptosis in the glioma microenvironment is still poorly understood. We characterized the expression of necroptosis-related genes (NRGs) within glioma samples at both the genetic and transcriptional levels, identifying three distinct subtypes. Additionally, we constructed a risk score, which is capable of accurately predicting patient prognosis, correlates with tumor mutation burden (TMB), tumor stem cell index (CSC), immune checkpoints, and predicts tumor drug sensitivity. To facilitate its application in the clinic, we developed a nomogram and demonstrated that it predicts the prognosis of glioma patients with good accuracy and reliability using multiple datasets. We examined the function of necroptosis in the tumor microenvironment (TME) and the prognosis of gliomas, which may be useful for guiding individualized treatment plans for gliomas targeting necroptosis.
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This article was submitted to Cancer Immunity and Immunotherapy, a section of the journal Frontiers in Oncology
Edited by: Quan Cheng, Central South University, China
Reviewed by: Zixiang Cong, Nanjing University, China; Xinwei Han, Zhengzhou University, China; Weimin Zhong, Xiamen Fifth Hospital, China
These authors have contributed equally to this work and share first authorship
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2022.899443