Dietary Red Meat Adversely Affects Disease Severity in a Pig Model of DSS-Induced Colitis Despite Reduction in Colonic Pro-Inflammatory Gene Expression

• Published in: Nutrients Vol. 12; no. 6; p. 1728
• Main Authors: Nielsen, Tina S, Fredborg, Marlene, Theil, Peter K, Yue, Yuan, Bruhn, Lærke V, Andersen, Vibeke, Purup, Stig
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 09.06.2020; MDPI
• Subjects: Animals; Antibiotics; Body Weight; Cattle; Chemokines; Colitis - chemically induced; Colitis - pathology; Colitis - physiopathology; Colon; Colon - metabolism; Colon - pathology; Cytokines; Dextran; Dextran sulfate; Dextran Sulfate - pharmacology; dextran sulfate sodium; Diet; Diet - adverse effects; Disease; Disease Models, Animal; Eating; Epidemiology; Fasting; Feces; Feeds; Gene expression; Gene Expression - physiology; histology; Hogs; inflammation; Inflammation - genetics; Inflammation - pathology; Inflammatory bowel disease; Inflammatory bowel diseases; Interleukin 6; Interleukin 8; Intestinal Mucosa - immunology; Intestine; Laboratory animals; Male; Meat; Mucosa; Pathogenesis; Permeability; porcine; Red Meat - adverse effects; Risk analysis; Risk Factors; Small intestine; Sus scrofa; Ulcerative colitis; Denmark; histology; inflammation; dextran sulfate sodium; porcine; diet; gene expression; inflammatory bowel disease

Diet plays a substantial role in the pathogenesis and management of ulcerative colitis (UC), and epidemiologic studies indicate an association between red meat intake and increased risk of UC development. Therefore, we evaluated the effect of a red meat diet on dextran sulfate sodium (DSS)-induced c...