The emerging potentials of lncRNA DRAIC in human cancers

Long non-coding RNA (lncRNA) is a subtype of noncoding RNA that has more than 200 nucleotides. Numerous studies have confirmed that lncRNA is relevant during multiple biological processes through the regulation of various genes, thus affecting disease progression. The lncRNA DRAIC, a newly discovere...

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Published inFrontiers in oncology Vol. 12; p. 867670
Main Authors Yao, Qinfan, Zhang, Xiuyuan, Chen, Dajin
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 04.08.2022
Subjects
application
biological function
DRAIC
lncRNA
mechanism
Oncology
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Summary:Long non-coding RNA (lncRNA) is a subtype of noncoding RNA that has more than 200 nucleotides. Numerous studies have confirmed that lncRNA is relevant during multiple biological processes through the regulation of various genes, thus affecting disease progression. The lncRNA DRAIC, a newly discovered lncRNA, has been found to be abnormally expressed in a variety of diseases, particularly cancer. Indeed, the dysregulation of DRAIC expression is closely related to clinicopathological features. It was also reported that DRAIC is key to biological functions such as cell proliferation, autophagy, migration, and invasion. Furthermore, DRAIC is of great clinical significance in human disease. In this review, we discuss the expression signature, clinical characteristics, biological functions, relevant mechanisms, and potential clinical applications of DRAIC in several human diseases.
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Reviewed by: Juan Li, Zhengzhou University, China; Giovanni Blandino, Hospital Physiotherapy Institutes (IRCCS), Italy
Edited by: Hernandes F. Carvalho, State University of Campinas, Brazil
This article was submitted to Molecular and Cellular Oncology, a section of the journal Frontiers in Oncology
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2022.867670