Signalling pathways in the osteogenic differentiation of periodontal ligament stem cells

Periodontal ligament stem cells (PDLSCs) have multidirectional differentiation potential and self-renewal abilities and are important seed cells for the regenerative repair of periodontal tissues. In recent years, many studies have identified multiple signalling pathways involved in regulating the o...

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Bibliographic Details
Published inOpen life sciences Vol. 18; no. 1; p. 20220706
Main Authors Ru, Liuyu, Pan, Bowen, Zheng, Jiwei
Format Journal Article
LanguageEnglish
Published De Gruyter 11.09.2023
Subjects
inflammatory environment
osteogenic differentiation
periodontal ligament stem cells
Review
signalling pathways
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Summary:Periodontal ligament stem cells (PDLSCs) have multidirectional differentiation potential and self-renewal abilities and are important seed cells for the regenerative repair of periodontal tissues. In recent years, many studies have identified multiple signalling pathways involved in regulating the osteogenic differentiation of PDLSCs in an inflammatory environment. In this article, we review the osteogenic differentiation of PDLSCs in an inflammatory environment in terms of signalling pathways and provide new ideas for the regenerative treatment of periodontal tissues. PDLSCs possess multidirectional differentiation potential and self-renewal ability. In the inflammatory environment, signalling pathways, such as Wnt/β-catenin, Wnt/Ca , Wnt/PCP, NF-κB, MAPK, BMPs, and PI3K/AKT, are involved in regulating the osteogenic differentiation of PDLSCs. In addition, multiple signalling pathways that interact with microRNAs play crucial roles in the osteogenic differentiation of PDLSCs.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ISSN:2391-5412
2391-5412
DOI:10.1515/biol-2022-0706