Bottom-Up Fabrication of Multilayer Enteric Devices for the Oral Delivery of Peptides

• Published in: Pharmaceutical research Vol. 36; no. 6; pp. 89 - 12
• Main Authors: Nemeth, Cameron L., Lykins, William R., Tran, Huyen, ElSayed, Mohamed E. H., Desai, Tejal A.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.06.2019; Springer; Springer Nature B.V
• Subjects: 3D printing; Biochemistry; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Computer simulation; Drug delivery; Drug delivery systems; Drugs; Fabrication; Inkjet printing; Insulin; Intestine; Kinetics; Levetiracetam; Medical Law; Peptides; Pharmacology/Toxicology; Pharmacy; Printing; Research Paper; Vehicles; Bottom-up fabrication process; enteric polymers; planar microdevices; oral peptide delivery
• ISSN: 0724-8741; 1573-904X
• DOI: 10.1007/s11095-019-2618-3

Purpose To develop a planar, asymmetric, micro-scale oral drug delivery vehicle by i) fabricating microdevice bodies with enteric materials, ii) efficiently and stably loading sensitive drug molecules, and iii) capping microdevices for controlled drug release. Methods Picoliter-volume inkjet printing was used to fabricate microdevices through additive manufacturing via drop-by-drop deposition of enteric polymer materials. Microdevice bodies with reservoirs are fabricated through deposition of an enteric polymer, Eudragit FS 30 D. A model API, insulin, was loaded into each microdevice and retained its stability during printing and release. Eudragit L 100 and/or S 100 were used to cap microdevices and control the kinetics of insulin release in simulated intestinal conditions. Results Microdevice morphologies and size can be tuned on the fly based on printing parameters to span from the microscale to the mesoscale. Insulin retained its stability throughout device fabrication and during in vitro release in simulated intestinal conditions. Insulin release kinetics, from burst release to no release, can be tailored by controlling the blend of the Eudragit capping material. Conclusion This approach represents a uniquely scalable and flexible strategy for microdevice fabrication that overcomes limitations in loading sensitive biologics and in the tuneability of device geometries that are inherent to traditional microfabrication strategies.