Comment on: "Melanisation of Aspergillus terreus-Is Butyrolactone I Involved in the Regulation of Both DOPA and DHN Types of Pigments in Submerged Culture? Microorganisms 2017, 5, 22"

A recent article by Palonen et al. describes the effect of butyrolactone I on the expression of a secondary metabolite biosynthesis gene cluster from that shows similarities to fusarubin biosynthesis gene clusters from species. The authors claim that two different types of pigments are formed in con...

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Bibliographic Details
Published inMicroorganisms (Basel) Vol. 5; no. 2; p. 34
Main Authors Geib, Elena, Brock, Matthias
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 21.06.2017
MDPI
Subjects
Bioinformatics
Biosynthesis
Butyrolactone
Comment
Conidia
Dihydroxyphenylalanine
Fusarium
Gene clusters
Gene expression
Melanin
Metabolites
Microorganisms
Pigments
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Summary:A recent article by Palonen et al. describes the effect of butyrolactone I on the expression of a secondary metabolite biosynthesis gene cluster from that shows similarities to fusarubin biosynthesis gene clusters from species. The authors claim that two different types of pigments are formed in conidia, whereby one pigment is termed a DOPA-type melanin and the second a DHN-type melanin. Unfortunately, the terminology of the classification of melanin-types requires revision as Asp-melanin present in conidia is clearly distinct from DOPA-melanins. In addition, some hypotheses in this manuscript are based on questionable data published previously, resulting in incorrect conclusions. Finally, as biochemical data are lacking and metabolite production is only deduced from bioinformatics and transcriptomic data, the production of a second pigment type in conidia appears highly speculative.
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ISSN:2076-2607
2076-2607
DOI:10.3390/microorganisms5020034