ALDH1A1 in Cancers: Bidirectional Function, Drug Resistance, and Regulatory Mechanism

• Published in: Frontiers in oncology Vol. 12; p. 918778
• Main Authors: Yue, Hanxun, Hu, Zenan, Hu, Rui, Guo, Zeying, Zheng, Ya, Wang, Yuping, Zhou, Yongning
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 22.06.2022
• Subjects: aldehyde dehydrogenases; cancer stem cell; carcinogenesis; drug resistance; hepatocellular carcinoma; Oncology

Aldehyde dehydrogenases 1 family member A1(ALDH1A1) gene codes a cytoplasmic enzyme and shows vital physiological and pathophysiological functions in many areas. ALDH1A1 plays important roles in various diseases, especially in cancers. We reviewed and summarized representative correlative studies an...