ALDH1A1 in Cancers: Bidirectional Function, Drug Resistance, and Regulatory Mechanism

Aldehyde dehydrogenases 1 family member A1(ALDH1A1) gene codes a cytoplasmic enzyme and shows vital physiological and pathophysiological functions in many areas. ALDH1A1 plays important roles in various diseases, especially in cancers. We reviewed and summarized representative correlative studies an...

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Published inFrontiers in oncology Vol. 12; p. 918778
Main Authors Yue, Hanxun, Hu, Zenan, Hu, Rui, Guo, Zeying, Zheng, Ya, Wang, Yuping, Zhou, Yongning
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 22.06.2022
Subjects
aldehyde dehydrogenases
cancer stem cell
carcinogenesis
drug resistance
hepatocellular carcinoma
Oncology
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Summary:Aldehyde dehydrogenases 1 family member A1(ALDH1A1) gene codes a cytoplasmic enzyme and shows vital physiological and pathophysiological functions in many areas. ALDH1A1 plays important roles in various diseases, especially in cancers. We reviewed and summarized representative correlative studies and found that ALDH1A1 could induce cancers via the maintenance of cancer stem cell properties, modification of metabolism, promotion of DNA repair. ALDH1A1 expression is regulated by several epigenetic processes. ALDH1A1 also acted as a tumor suppressor in certain cancers. The detoxification of ALDH1A1 often causes chemotherapy failure. Currently, ALDH1A1-targeted therapy is widely used in cancer treatment, but the mechanism by which ALDH1A1 regulates cancer development is not fully understood. This review will provide insight into the status of ALDH1A1 research and new viewpoint for cancer therapy.
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Reviewed by: Junlong Zhuang, Nanjing Drum Tower Hospital, China; Jamal Majidpoor, Iran University of Medical Sciences, Iran
This article was submitted to Cancer Genetics, a section of the journal Frontiers in Oncology
Edited by: Ira Ida Skvortsova, Innsbruck Medical University, Austria
These authors have contributed equally to this work
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2022.918778