Evaluation of polymeric PLGA nanoparticles conjugated to curcumin for use in aPDT
Antimicrobial photodynamic therapy (aPDT) involves the association of a photosensitizing agent with a light source with the goal of causing apoptosis or microbial lysing. The use of compounds with natural active principles is gaining prominence throughout the world. Several studies from groups that...
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Published in | Brazilian Journal of Pharmaceutical Sciences Vol. 53; no. 2 |
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Main Authors | , , , , , , , , , , , , |
Format | Journal Article |
Language | English Portuguese |
Published |
Sao Paulo
Universidade de Sao Paulo Faculdade de Ciencias
01.01.2017
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas Universidade de São Paulo |
Subjects | |
Online Access | Get full text |
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Summary: | Antimicrobial photodynamic therapy (aPDT) involves the association of a photosensitizing agent with a light source with the goal of causing apoptosis or microbial lysing. The use of compounds with natural active principles is gaining prominence throughout the world. Several studies from groups that are linked to the development of innovations in the pharmaceutical market have used natural dyes, such as curcumin, the efficacy of which has been demonstrated in aPDT trials. Difficulties related to physicochemical stability, solubility and cell penetration are some of the challenges associated with this field. The present work aimed to prepare, investigate the characteristics and improve the photodynamic activity of PLGA-based nanoparticles loaded with curcumin for use in aPDT therapy. Using the simple technique of emulsion during the evaporation of a solvent, the particles were built, characterized and tested against microorganisms with importance for medicine and dentistry. The results revealed that the particles were able to protect the curcumin against degradation and eliminate some microorganism species at nanomolar concentrations. |
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ISSN: | 1984-8250 2175-9790 1984-8250 2175-9790 |
DOI: | 10.1590/s2175-97902017000216043 |