Directed Networks as a Novel Way to Describe and Analyze Cardiac Excitation: Directed Graph Mapping
Networks provide a powerful methodology with applications in a variety of biological, technological and social systems such as analysis of brain data, social networks, internet search engine algorithms, etc. To date, directed networks have not yet been applied to characterize the excitation of the h...
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Published in | Frontiers in physiology Vol. 10; p. 1138 |
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Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Frontiers Media S.A
10.09.2019
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Subjects | |
Online Access | Get full text |
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Summary: | Networks provide a powerful methodology with applications in a variety of biological, technological and social systems such as analysis of brain data, social networks, internet search engine algorithms, etc. To date, directed networks have not yet been applied to characterize the excitation of the human heart. In clinical practice, cardiac excitation is recorded by multiple discrete electrodes. During (normal) sinus rhythm or during cardiac arrhythmias, successive excitation connects neighboring electrodes, resulting in their own unique directed network. This in theory makes it a perfect fit for directed network analysis. In this study, we applied directed networks to the heart in order to describe and characterize cardiac arrhythmias. Proof-of-principle was established using
in-silico
and clinical data. We demonstrated that tools used in network theory analysis allow determination of the mechanism and location of certain cardiac arrhythmias. We show that the robustness of this approach can potentially exceed the existing state-of-the art methodology used in clinics. Furthermore, implementation of these techniques in daily practice can improve the accuracy and speed of cardiac arrhythmia analysis. It may also provide novel insights in arrhythmias that are still incompletely understood. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors have contributed equally to this work and are second authors Edited by: Mark Potse, Inria Bordeaux - Sud-Ouest Research Centre, France This article was submitted to Cardiac Electrophysiology, a section of the journal Frontiers in Physiology These authors have contributed equally to this work and are first authors Reviewed by: Caroline Helen Roney, King's College London, United Kingdom; Maria S. Guillem, Polytechnic University of Valencia, Spain; Arne Van Hunnik, Maastricht University, Netherlands |
ISSN: | 1664-042X 1664-042X |
DOI: | 10.3389/fphys.2019.01138 |