Dose dependent treatment with isotretinoin induces more changes in the ileum than in the duodenum and jejunum in Wistar rats

Highlights • A dose dependent treatment with isotretinoin solution is tested. • Duodenum, jejunum and ileum histology structure are observed after the treatment. • Duodenum and jejunum were the less affected. • Ileum is the most affected portion with alteration in goblet cells pattern.

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Bibliographic Details
Published inTissue & cell Vol. 49; no. 2; pp. 203 - 208
Main Authors Thomazini, B.F, Dolder, M.A.H
Format Journal Article
LanguageEnglish
Published Scotland Elsevier Ltd 01.04.2017
Elsevier Science Ltd
Subjects
Acne
Acne Vulgaris - drug therapy
Acne Vulgaris - pathology
Advanced Basic Science
Animals
Crypts
Disease control
Disease Models, Animal
Duodenum
Duodenum - drug effects
Goblet cell
Goblet cells
Goblet Cells - drug effects
Goblet Cells - pathology
Histology
Humans
Ileum
Ileum - drug effects
Intestinal Mucosa - drug effects
Intestine, Small - drug effects
Intestine, Small - pathology
Isotretinoin
Isotretinoin - administration & dosage
Isotretinoin - adverse effects
Jejunum
Jejunum - drug effects
Male
Morphometry
Mucosa
Oils & fats
Patients
Rats
Rats, Wistar
Scanning electron microscopy
Sebaceous gland
Sebaceous glands
Security
Skin diseases
Small intestine
Soybean oil
Soybeans
Villus
Vitamin A
Goblet cell
Isotretinoin
Histology
Morphometry
Small intestine
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Summary:Highlights • A dose dependent treatment with isotretinoin solution is tested. • Duodenum, jejunum and ileum histology structure are observed after the treatment. • Duodenum and jejunum were the less affected. • Ileum is the most affected portion with alteration in goblet cells pattern.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0040-8166
1532-3072
DOI:10.1016/j.tice.2017.03.003