Sample concentration in a microfluidic paper-based analytical device using ion concentration polarization

• Published in: Sensors and actuators. B, Chemical Vol. 222; pp. 735 - 740
• Main Authors: Phan, Dinh-Tuan, Shaegh, Seyed Ali Mousavi, Yang, Chun, Nguyen, Nam-Trung
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.01.2016
• Subjects: Devices; Dyes; Fluorescence; Ion concentration; Ion concentration polarization; Lab on a chip; Mathematical analysis; Microfluidics; Nanofluidics; Paper-based microfluidics; Polarization; Sample concentration; Sample preparation; Paper-based microfluidics; Ion concentration polarization; Nanofluidics; Sample preparation; Lab on a chip; Sample concentration
• ISSN: 0925-4005; 1873-3077
• DOI: 10.1016/j.snb.2015.08.127

•A low-cost approach for sample concentration on a microfluidic paper-based platform.•Fast establishment of ion depletion zone at an integrated nanoporous junction.•Fast sample concentration through a combination of transport phenomena including ion concentration polarization, electrophoresis and electrosmosis. We report a low-cost approach for sample concentration in a microfluidic paper-based analytical device using ion concentration polarization. This device platform can attain liquid sample filling by capillary suction through the microporous paper and ion selective transport through a nanoporous polymer matrix under DC electric field. The device demonstrated a fast depletion of fluorescent dye samples and can serve as an effective microfluidic concentrator of fluorescent dye with 60-fold concentration enhancement achieved within 200s. The device fabrication is simply based on paper cutting and lamination without the need of lithography and printing of hydrophobic material such as wax. The lamination approach presented in this paper has the potential to be transferred to a large-scale production of paper-based analytical devices.