Tipping the Balance toward Longevity

Genetic experiments in C. elegans suggested that SIR2, an NAD-dependent protein deacetylase, acts through FOXO/DAF-16 transcription factor to prolong life. Recent studies show that mammalian SIR2 deacetylates FOXO, and may maximize survival by tempering cell death and increasing stress resistance.

Saved in:
Bibliographic Details
Published inDevelopmental Cell Vol. 6; no. 3; pp. 315 - 316
Main Author Antebi, Adam
Format Book Review Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.03.2004
Subjects
Animals
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Death - genetics
Cell Death - physiology
Forkhead Transcription Factors
Gene Silencing
Longevity - genetics
Longevity - physiology
Sirtuins - metabolism
Sirtuins - physiology
Transcription Factors - physiology
Tumor Suppressor Protein p53 - metabolism
Online AccessGet full text

Cover

More Information
Summary:Genetic experiments in C. elegans suggested that SIR2, an NAD-dependent protein deacetylase, acts through FOXO/DAF-16 transcription factor to prolong life. Recent studies show that mammalian SIR2 deacetylates FOXO, and may maximize survival by tempering cell death and increasing stress resistance.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
ObjectType-Article-1
ObjectType-Feature-2
ISSN:1534-5807
1878-1551
DOI:10.1016/S1534-5807(04)00068-1