Treatment of Recurrent Herpes Simplex Labialis with Oral Acyclovir

• Published in: The Journal of infectious diseases Vol. 161; no. 2; pp. 185 - 190
• Main Authors: Spruance, Spotswood L., Stewart, Jeffery C. B., Rowe, Nathaniel H., McKeough, Mark B., Wenerstrom, Gay, Freeman, Donna J.
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.02.1990; University of Chicago Press
• Subjects: Acyclovir - administration & dosage; Acyclovir - therapeutic use; Administration, Oral; Adult; Aged; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Antivirals; Biological and medical sciences; Double-Blind Method; Erythema; Female; Genital herpes; Healing; Herpes labialis; Herpes Labialis - drug therapy; Herpes simplex; Humans; Infections; Lesions; Major Articles; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Placebos; Prospective Studies; Randomized Controlled Trials as Topic; Recurrence; Self Administration; Simplexvirus - drug effects; Simplexvirus - isolation & purification; Viruses; Infection; Human; Chemotherapy; Lip; Skin disease; Treatment; Viral disease; Oral administration; Herpes; Antiviral; Controlled therapeutic trial; Hard capsule
• ISSN: 0022-1899; 1537-6613
• DOI: 10.1093/infdis/161.2.185

In a double-blind, randomized, patient-initiated clinical trial, 174 nonimmunocompromised patients with a history of virus-culture-confirmed herpes simplex labialis were treated with acyclovir capsules, 400 mg five times daily for 5 days, or placebo capsules. For 97% of the patients, treatment started within 1 h of the first sign or symptom of a recurrence. The frequency of positive lesion virus cultures was significantly lower among acyclovir-treated subjects (29/114,25%) than among placebo-treated subjects (29/60,48%; P = .004). Drug treatment did not affect the development of lesions, measured by the frequency of macular and papular (aborted) lesions and mean maximum lesion size. However, acyclovir hastened lesion resolution among the patients who could start treatment in the prodrome or erythema lesion stage. For this group, the mean duration of pain was reduced by 36% (P = .02)and the mean healing time to loss of crust by 27% (P = .03). Thus, oral acyclovir alleviated some of the clinical manifestations of herpes simplex labialis.