Endothelial to Mesenchymal Transition: An Insight in Atherosclerosis

Atherosclerosis is a fundamental disease of the cardiovascular system that leads to high morbidity and mortality worldwide. The endothelium is the first protective barrier in atherosclerosis. Endothelial cells have the potential to be transformed into mesenchymal cells, in a process termed endotheli...

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Published inFrontiers in cardiovascular medicine Vol. 8; p. 734550
Main Authors Huang, Qingyan, Gan, Yuhong, Yu, Zhikang, Wu, Heming, Zhong, Zhixiong
Format Journal Article
LanguageEnglish
Published Frontiers Media S.A 17.09.2021
Subjects
atherosclerosis
Cardiovascular Medicine
EndMT-associated marker
endothelial to mesenchymal transition
plasticity of endothelial cells
regulating mechanisms
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Summary:Atherosclerosis is a fundamental disease of the cardiovascular system that leads to high morbidity and mortality worldwide. The endothelium is the first protective barrier in atherosclerosis. Endothelial cells have the potential to be transformed into mesenchymal cells, in a process termed endothelial to mesenchymal transition (EndMT). On the one hand, EndMT is known to contribute to atherosclerosis by inducing a number of phenotypes ranging from endothelial cell dysfunction to plaque formation. On the other hand, risk factors for atherosclerosis can lead to EndMT. A substantial body of evidence has suggested that EndMT induces the development of atherosclerosis; therefore, a deeper understanding of the molecular mechanisms underlying EndMT in atherosclerosis might provide insights to reverse this condition.
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Edited by: Lina A. Shehadeh, University of Miami, United States
These authors have contributed equally to this work
Reviewed by: Zhihua Wang, Chinese Academy of Medical Sciences and Peking Union Medical College, China; Prachi Umbarkar, University of Alabama at Birmingham, United States
This article was submitted to Cardiovascular Metabolism, a section of the journal Frontiers in Cardiovascular Medicine
ISSN:2297-055X
2297-055X
DOI:10.3389/fcvm.2021.734550