Flavonoids: Broad Spectrum Agents on Chronic Inflammation

Flavonoids are major plant constituents with numerous biological/pharmacological actions both and . Of these actions, their anti-inflammatory action is prominent. They can regulate transcription of many proinflammatory genes such as cyclooxygenase- 2/inducible nitric oxide synthase and many cytokine...

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Bibliographic Details
Published inBiomolecules & therapeutics Vol. 27; no. 3; pp. 241 - 253
Main Authors Lim, Hyun, Heo, Moon Young, Kim, Hyun Pyo
Format Journal Article
LanguageEnglish
Published Korea (South) The Korean Society of Applied Pharmacology 01.05.2019
한국응용약물학회
Subjects
Invited Review
약학
Inflammaging
Meta-inflammation
Chronic inflammation
Flavonoid
Therapeutics
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Summary:Flavonoids are major plant constituents with numerous biological/pharmacological actions both and . Of these actions, their anti-inflammatory action is prominent. They can regulate transcription of many proinflammatory genes such as cyclooxygenase- 2/inducible nitric oxide synthase and many cytokines/chemokines. Recent studies have demonstrated that certain flavonoid derivatives can affect pathways of inflammasome activation and autophagy. Certain flavonoids can also accelerate the resolution phase of inflammation, leading to avoiding chronic inflammatory stimuli. All these pharmacological actions with newly emerging activities render flavonoids to be potential therapeutics for chronic inflammatory disorders including arthritic inflammation, meta-inflammation, and inflammaging. Recent findings of flavonoids are summarized and future perspectives are presented in this review.
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http://www.biomolther.org/journal/view.html?uid=1098&vmd=Full
ISSN:1976-9148
2005-4483
DOI:10.4062/biomolther.2019.034