Development of a human iPSC line (SMBCi004-A) from a patient with Gaucher disease

A human induced pluripotent stem cell (iPSC) line was generated from the urine cells of a 8-year-old female with Gaucher disease with the homozygous changes c.1448 T>C in the GBA gene. Reprogramming factors OCT4, SOX2, KLF4, and miR-302–367 were delivered using a non-integrative plasmid. Our iPSC...

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Published inStem cell research Vol. 48; p. 101989
Main Authors Zhao, Qingyang, Cui, Yazhou, Wang, Jing, Shi, Liang, Qi, Zijuan, Luan, Jing, Zhang, Yuang, Zhou, Xiaoyan, Han, Jinxiang
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.10.2020
Elsevier
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Summary:A human induced pluripotent stem cell (iPSC) line was generated from the urine cells of a 8-year-old female with Gaucher disease with the homozygous changes c.1448 T>C in the GBA gene. Reprogramming factors OCT4, SOX2, KLF4, and miR-302–367 were delivered using a non-integrative plasmid. Our iPSCs showed complete pluripotency, normal genetic stability, and the ability to differentiate into three germ layers.
Bibliography:ObjectType-Case Study-2
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ISSN:1873-5061
1876-7753
DOI:10.1016/j.scr.2020.101989