A distinct profile of serum levels of soluble intercellular adhesion molecule-1 and intercellular adhesion molecule-3 in mycosis fungoides and Sézary syndrome

• Published in: Journal of the American Academy of Dermatology Vol. 61; no. 2; pp. 263 - 270
• Main Authors: López-Lerma, Ingrid, MD, Estrach, Maria Teresa, MD
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.08.2009; Elsevier
• Subjects: Adult; Aged; Antigens, CD - blood; Biological and medical sciences; Biomarkers - blood; Biopsy, Needle; Case-Control Studies; Cell Adhesion Molecules - blood; cutaneous T-cell lymphoma; Dermatology; Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Hematologic and hematopoietic diseases; Humans; Immunohistochemistry; Intercellular Adhesion Molecule-1 - blood; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis; Male; Medical sciences; Middle Aged; Mycosis Fungoides - blood; Mycosis Fungoides - immunology; Mycosis Fungoides - pathology; Neoplasm Staging; Probability; Prognosis; Reference Values; Risk Assessment; Sensitivity and Specificity; Sezary Syndrome - blood; Sezary Syndrome - immunology; Sezary Syndrome - pathology; Skin Neoplasms - blood; Skin Neoplasms - immunology; Skin Neoplasms - pathology; Solubility; soluble E-selectin; soluble intercellular adhesion molecule-1; soluble intercellular adhesion molecule-3; soluble vascular cell adhesion molecule-1; Statistics, Nonparametric; soluble cell adhesion molecule; CTCL; cutaneous T-cell lymphoma; LFA; lymphocyte function-associated antigen; soluble E-selectin; sE-selectin; sVCAM-1; aCTCL; mycosis fungoides; sICAM; soluble intercellular adhesion molecule-3; soluble vascular cell adhesion molecule-1; LDH; soluble intercellular adhesion molecule-1; cell adhesion molecule; MF; soluble vascular cell adhesion molecule; ICAM; lactate dehydrogenase; sCAM; advanced cutaneous T-cell lymphoma; CAM; soluble intercellular adhesion molecule; VCAM-1; vascular cell adhesion molecule; intercellular adhesion molecule; Skin disease; Intercellular adhesion molecule 1; Dermatology; Cell adhesion molecule; Mycosis fungoides; Malignant hemopathy; Non Hodgkin lymphoma; Peripheral T cell lymphoma; Chronic; Cutaneous hematologic disease; Sezary syndrome; Lymphoproliferative syndrome; Serum; Cancer
• ISSN: 0190-9622; 1097-6787
• DOI: 10.1016/j.jaad.2009.03.041

Background Cell adhesion molecules (CAMs) play a pivotal role in cutaneous localization of T cells. Tissue-selective localization of T lymphocytes to the skin is crucial for immune surveillance and in the pathogenesis of skin disorders. Objective To detect the profile of soluble CAMs in patients with cutaneous T-cell lymphoma (CTCL), we investigated the levels of intercellular adhesion molecule-1 (ICAM-1, soluble ICAM-1 [sICAM-1]); intercellular adhesion molecule-3 (sICAM-3); vascular cell adhesion molecule-1 (sVCAM-1); and E-selectin (sE-selectin) in sera from patients with T-cell–mediated skin diseases. Methods Serum levels of the 4 CAMs were measured by enzyme-linked immunosorbent assay in 42 participants including 11 patients with early stages of CTCL; 7 with advanced stages of CTCL including Sézary syndrome; 12 with inflammatory skin diseases (psoriasis and atopic dermatitis); 8 with skin diseases that may evolve into CTCL; and healthy individuals. Levels were correlated with biological parameters known as prognostic factors in non-Hodgkin lymphomas. Results In patients with CTCL, significantly increased levels of sICAM-1 and sICAM-3 were found when compared with healthy individuals and patients with inflammatory dermatosis. Soluble E-selectin and sVCAM-1 levels were not increased. There were significant positive correlations between sICAM-1 and sICAM-3 levels and each of them with β2-microglobulin levels. Limitations Limited number of patients was a limitation. Conclusion There is a distinct profile of soluble CAMs in patients with CTCL. However, future studies with a larger group of patients are needed to confirm these findings. We propose that high sICAM-1 and sICAM-3 levels have important implications in the context of immune response and immune surveillance in these patients.