Investigating the Brain Neural Mechanism when Signature Objects were Masked during a Scene Categorization Task using Functional MRI

• Published in: Neuroscience Vol. 388; pp. 248 - 262
• Main Authors: Miao, Qiaomu, Zhang, Gaoyan, Yan, Weiran, Liu, Baolin
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 15.09.2018
• Subjects: functional connectivity; functional magnetic resonance imaging; lateral occipital complex; scene categorization; signature object masked; lateral occipital complex; functional connectivity; scene categorization; signature object masked; functional magnetic resonance imaging
• ISSN: 0306-4522; 1873-7544; 1873-7544
• DOI: 10.1016/j.neuroscience.2018.07.030

•Behavioral responses were severely degraded as more signature objects were masked.•The LOC showed a decrease in activations and changes in functional connectivity (FC) with high-level cognitive regions.•FC changes were observed within the fronto-parietal network, possibly due to higher cognitive demand.•Middle temporal gyrus interacted with supramarginal gyrus and insula in the processing of semantic relation.•The changed FC significantly correlated with scene categorization behaviors. Objects play vital roles in scene categorization. Although a number of studies have researched on the neural responses during object and object-based scene recognition, few studies have investigated the neural mechanism underlying object-masked scene categorization. Here, we used functional magnetic resonance imaging (fMRI) to measure the changes in brain activations and functional connectivity (FC) while subjects performed a visual scene-categorization task with different numbers of ‘signature objects’ masked. The object-selective region in the lateral occipital complex (LOC) showed a decrease in activations and changes in FC with the default mode network (DMN), indicating changes in object attention after the masking of signature objects. Changes in top-down modulation effect were revealed in the FC from the dorsolateral prefrontal cortex (DLPFC) to LOC and the extrastriate visual cortex, possibly participating in conscious object recognition. The whole-brain analyses showed the participation of fronto-parietal network (FPN) in scene categorization judgment, and right DLPFC served as the core hub in this network. Another core hub was found in left middle temporal gyrus (MTG) and its connection with middle cingulate cortex (MCC), supramarginal gyrus (SMG) and insula might serve in the processing of motor response and the semantic relations between objects and scenes. Brain-behavior correlation analysis substantiated the contributions of the FC to the different processes in the object-masked scene-categorization tasks. Altogether, the results suggest that masking of objects significantly affected the object attention, cognitive demand, top-down modulation effect, and semantic judgment.