Development of left ventricular systolic and diastolic function in preterm infants during the first month of life: A prospective follow-up study

• Published in: The Journal of pediatrics Vol. 139; no. 4; pp. 539 - 545
• Main Authors: Kozák-Bárány, Andrea, Jokinen, Eero, Saraste, Markku, Tuominen, Juhani, Välimäki, Ilkka
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.10.2001; Elsevier
• Subjects: Biological and medical sciences; Blood Flow Velocity - physiology; Child Development - physiology; Diastole - physiology; Echocardiography, Doppler; Female; Follow-Up Studies; Fundamental and applied biological sciences. Psychology; Heart; Humans; Infant, Newborn; Infant, Premature - physiology; Male; Prospective Studies; Stroke Volume - physiology; Systole - physiology; Ventricular Function, Left - physiology; Vertebrates: cardiovascular system; DT; AFF; BSA; DFT; EFF; FSA; HR; LV; mFS; FS; Human; Premature; Newborn; Follow up study; Diastolic time; Systolic time; Left ventricle performance; Pattern analysis; Postnatal development; Comparative study
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1067/mpd.2001.118199

Objectives: We studied the left ventricular systolic and diastolic function in preterm infants during the first month of life in comparison with the respective patterns in term neonates. Study design: Serial 2-dimensional/M-mode and Doppler transmitral flow velocity measurements were performed in 20 preterm (gestational age, 32 to 36 weeks) and 25 term infants between days 2 and 5 after birth and at age 1 month. Results: After birth, the early velocity, early integral, early filling fraction, early and atrial velocity ratios, and early and atrial integral ratios were lower in the preterm than in the term infants (P < .01). During the first 4 weeks of life, these values, the atrial velocity, and the atrial integral increased gradually, whereas the atrial filling fraction, diastolic filling time, and deceleration time of early diastolic filling decreased slightly with postnatal age (P < .01) in the preterm infants. At age 1 month their diastolic function reached the level of term infants with the exception of early and atrial integral ratios and atrial filling fraction. The measures of systolic performance were within normal range, but midwall fractional shortening at 2 to 5 days (P < .05), and fractional shortening area (P < .05), as well as midwall fractional shortening (P < .01) at 1 month of age, were slightly inferior in the preterm than in the term infants. During the first month the left ventricular mass and left ventricular mass/body surface area ratio increased more markedly in the preterm than term infants, significantly in both groups (P < .05). Conclusions: The preterm diastolic patterns represent a transition between the patterns of the fetus and those of term neonates. These changes reflect an improvement in the left ventricular diastolic function, more markedly in relaxation than in compliance. The postnatal increase in the transmitral measures and left ventricular mass suggest marked myocardial adaptation to the extrauterine environment in the preterm infant already during the first month. (J Pediatr 2001;139:539-45)