Serotonin and impulsive aggression

Aggression is a behavior with evolutionary origins, but is often both destructive and maladaptive in today’s society. Research over the past several decades has confirmed the involvement of neurotransmitter function in aggressive behavior. This research has centered around the “serotonin hypothesis....

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Bibliographic Details
Published inCNS spectrums Vol. 20; no. 3; pp. 295 - 302
Main Authors Coccaro, Emil F., Fanning, Jennifer R., Phan, K. Luan, Lee, Royce
Format Journal Article
LanguageEnglish
Published New York, USA Cambridge University Press 01.06.2015
Subjects
Aggression - physiology
Aggressiveness
Antisocial personality disorder
Binding sites
Blood platelets
Humans
Impulsive Behavior - drug effects
Impulsivity
Laboratories
Personality traits
Review Articles
Self destructive behavior
Serotonin
Serotonin - physiology
Serotonin Agents - therapeutic use
Suicidal behavior
Suicidal Ideation
Suicides & suicide attempts
serotonin
receptors
Aggression
neurotransmitters
neuroimaging
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Summary:Aggression is a behavior with evolutionary origins, but is often both destructive and maladaptive in today’s society. Research over the past several decades has confirmed the involvement of neurotransmitter function in aggressive behavior. This research has centered around the “serotonin hypothesis.” As this literature continues to grow, guided by pre-clinical research and aided by the application of increasingly sophisticated neuroimaging methodology, a more complex picture has emerged. As current pharmacological and therapeutic interventions are effective but imperfect, it is hoped that new insights into the neurobiology of aggression will reveal novel avenues for treatment of this destructive and costly behavior.
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ISSN:1092-8529
2165-6509
DOI:10.1017/S1092852915000310