Novel oligopeptide nanoprobe for targeted cancer cell imaging

Here we designed and constructed a tryptophan-phenylalanine-phenylalanine-tryptophan (WFFW) tetrapeptide, which generated photostable and tunable fluorescence emission signals from 340 nm to 500 nm. The WFFW tetrapeptide could self-assemble into a spherical nanostructure with enhanced fluorescence i...

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Bibliographic Details
Published inRSC advances Vol. 8; no. 54; pp. 30887 - 30893
Main Authors Ding, Wen-Qiang, Qin, Si-Yong, Cheng, Yin-Jia, Ma, Yi-Han, Zhang, Ai-Qing
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 01.01.2018
The Royal Society of Chemistry
Subjects
Aspartic acid
Cancer
Chemistry
Fluorescence
fluorescent dyes
Glycine
hydrogen bonding
Hydrogen bonds
image analysis
nanomaterials
neoplasm cells
neoplasms
Phenylalanine
Tryptophan
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Summary:Here we designed and constructed a tryptophan-phenylalanine-phenylalanine-tryptophan (WFFW) tetrapeptide, which generated photostable and tunable fluorescence emission signals from 340 nm to 500 nm. The WFFW tetrapeptide could self-assemble into a spherical nanostructure with enhanced fluorescence intensity. Driven by π–π stacking and hydrogen bond interaction, WFFW co-assembled with arginine-glycine-aspartic acid (RGD) modified WFFW to form a cancer-targeted fluorescent nanoprobe, which could selectively image the cancer cells.
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ISSN:2046-2069
2046-2069
DOI:10.1039/C8RA06034G