Diagnostic accuracy of demarcation using magnifying endoscopy with narrow-band imaging for Helicobacter pylori-uninfected undifferentiated-type early gastric cancer

• Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association Vol. 21; no. 6; pp. 988 - 997
• Main Authors: Horiuchi, Yusuke, Fujisaki, Junko, Yamamoto, Noriko, Yoshimizu, Shoichi, Ishiyama, Akiyoshi, Yoshio, Toshiyuki, Hirasawa, Toshiaki, Yamamoto, Yorimasa, Nagahama, Masatsugu, Takahashi, Hiroshi, Tsuchida, Tomohiro
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.11.2018; Springer Nature B.V
• Subjects: Abdominal Surgery; Accuracy; Aged; Cancer Research; Endoscopic Mucosal Resection - methods; Endoscopy; Eradication; Gastric cancer; Gastroenterology; Helicobacter Infections - pathology; Helicobacter Infections - therapy; Helicobacter pylori; Helicobacter pylori - pathogenicity; Humans; Inflammation; Intestine; Male; Medicine; Medicine & Public Health; Metaplasia; Middle Aged; Narrow Band Imaging - methods; Neutrophils; Oncology; Original Article; Pathogens; Stomach Neoplasms - pathology; Stomach Neoplasms - virology; Surgical Oncology; Gastric cancer; Endoscopic gastrointestinal surgery; Endoscopic resection; Helicobacter pylori
• ISSN: 1436-3291; 1436-3305; 1436-3305
• DOI: 10.1007/s10120-018-0819-9

Background It is unknown how the accuracy rate of diagnostic demarcation of undifferentiated-type early gastric cancers (UD-type EGCs) differs between patients uninfected with Helicobacter pylori ( H. pylori ) and patients with and without H. pylori eradication. This study assessed and compared the diagnostic accuracy rate in the H. pylori -uninfected group and the non- H. pylori eradication and H. pylori eradication groups. Methods Subjects were 81 patients with 81 lesions who underwent endoscopic submucosal dissection between January 2010 and January 2015. There were 21 lesions in the H. pylori -uninfected group, 27 in the H. pylori eradication group, and 33 in the non- H. pylori eradication group. The rate in the H. pylori -uninfected group was separately compared with the rates in the non- H. pylori eradication and H. pylori eradication groups, as was inflammatory cell infiltration. Results The diagnostic accuracy rates were 60.6% in the non- H. pylori eradication group, 92.2% in the H. pylori eradication group, and 100% in the H. pylori -uninfected group; the rate was significantly higher in the H. pylori -uninfected group than in the non- H. pylori eradication group, but no significant difference was observed between the H. pylori -uninfected group and the H. pylori eradication group. In addition, the H. pylori -uninfected and H. pylori eradication groups showed no significant differences in neutrophil infiltration and intestinal metaplasia, whereas the state in the H. pylori -uninfected group was significantly milder. Conclusions Because neutrophil infiltration was classified as mild or none, the accuracy of diagnostic demarcation was high in the H. pylori -uninfected and H. pylori eradication groups.