M-Current Suppression, Seizures and Lipid Metabolism: A Potential Link Between Neuronal Kv7 Channel Regulation and Dietary Therapies for Epilepsy

• Published in: Frontiers in physiology Vol. 11; p. 513
• Main Author: Hoshi, Naoto
• Format: Journal Article
• Language: English
• Published: Frontiers Media S.A 25.05.2020
• Subjects: epilepsy; Kv7 channel; medium chain fatty; palmitoylation; Physiology; regulation – physiological; valproic acid

Neuronal Kv7 channel generates a low voltage-activated potassium current known as the M-current. The M-current can be suppressed by various neurotransmitters that activate Gq-coupled receptors. Because the M-current stabilizes membrane potential at the resting membrane potential, its suppression tra...